1336. Alcohol Impregnated Caps and Ambulatory CLABSI: Multicenter Cluster Randomized, Crossover Trial

A Randomized Multicenter Trial

Multicenter Randomized Trial

Background Thrombolytic therapy reduces mortality after acute myocardial infarction, even when treatment is initiated relatively late after onset of symptoms. The mechanism underlying this survival benefit is incompletely understood. Methods and Results In a prospectively designed ancillary study of a randomized, placebo-controlled trial of late thrombolytic therapy (LATE), the signal-averaged ...

A Multicenter Randomized Trial

Background—Previous studies suggested that transplantation of autologous bone marrow–derived mononuclear cells (BMNCs) improves heart function in chronic chagasic cardiomyopathy. We report the results of the first randomized trial of BMNC therapy in chronic chagasic cardiomyopathy. Methods and Results—Patients 18 to 75 years of age with chronic chagasic cardiomyopathy, New York Heart Associatio...

Cluster Randomized Controlled Trial

The high prevalence and diversity of longer-term problems experienced by patients with stroke and their carers has long been recognized, but they remain poorly addressed by existing services. Postdischarge contact with therapy services is associated with improved outcomes. However, these interventions are generally time limited and have little effect on psychosocial outcome. National guidelines...

Empirical Power and Sample Size Calculations for Cluster-Randomized and Cluster-Randomized Crossover Studies

In recent years, the number of studies using a cluster-randomized design has grown dramatically. In addition, the cluster-randomized crossover design has been touted as a methodological advance that can increase efficiency of cluster-randomized studies in certain situations. While the cluster-randomized crossover trial has become a popular tool, standards of design, analysis, reporting and impl...